Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4gene.[5][6][7] It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (February 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene. 9 (2): 509–16. PMID8290261.
^Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, et al. (November 2014). "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo". Nature Cell Biology. 16 (11): 1069–79. doi:10.1038/ncb3053. PMID25327288. S2CID21172670.
Minoletti F, Butti MG, Coronelli S, Miozzo M, Sozzi G, Pilotti S, Tunnacliffe A, Pierotti MA, Bongarzone I (September 1994). "The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2". Genes, Chromosomes & Cancer. 11 (1): 51–7. doi:10.1002/gcc.2870110108. PMID7529046. S2CID45815041.
Jhiang SM, Smanik PA, Mazzaferri EL (April 1994). "Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma". Cancer Letters. 78 (1–3): 69–76. doi:10.1016/0304-3835(94)90033-7. PMID8180971.
Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G, Pierotti MA (June 1994). "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas". Cancer Research. 54 (11): 2979–85. PMID8187085.
Bongarzone I, Butti MG, Fugazzola L, Pacini F, Pinchera A, Vorontsova TV, Demidchik EP, Pierotti MA (June 1997). "Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas". Genomics. 42 (2): 252–9. doi:10.1006/geno.1997.4685. PMID9192845.